In Puzzle 22 nearly every players would immediately play AX 2m (42). However, this allows your opponent to play RE- bingos for big points and win the game.
The best play is the extremely un-intuitive eX in the same spot. This scores less and uses the extremely valuable blank tile, but greatly reduces your opponent’s bingo chances. In addition, even if your opponent does bingo, the reduced points and position of bingos (such as INTAGLIO) allows you to outscore many of those plays if your opponent draws the Q.