This position contains a myriad of various options. The most obvious options are scoring plays, such as RAPHE or HERMA at 1a or RALPH at 12k. These plays score well while also keeping a decent leave and block some opponent options.
Of these plays, I probably prefer RALPH. While scoring the least of these three, it blocks a substantial number of bingos and even a few scoring plays. The opening at 1a is not as dangerous as usual (since XJQZK have all been played) and the EM leave is better than the LP or LM leaves after HERMA and RAPHE.
You also have the option of setup plays. Two setups stand out: PRY and PLY, both at 3g, setting up HM at 1g for 56 next turn, for a sum of 81 over the next two turns (assuming the setup stays open and you don’t draw something even better).
Of these options, PLY is better. While you can block by hooking ILK-A, IRK can be blocked by playing DIRK, and will be blocked in that way more often. PLY also gives you even more potential to hit other plays when blocked, and even bingos on future turns some of the time.
PLY is also better than the longer plays, as the 81 point sum is more than you can expect from RALPH with a random 5 tile draw. While HM will sometimes be blocked, it usually won’t be, and HERMA for 41 is a decent backup play, and sometimes you’ll also get to play bingos or other strong plays with good draws.